Young and Van der Heijde define «as that disease of rapidly progressive clinical course that affects multiple joints with little or no response to drugs modifying the disease and marked disability, resulting in loss of work and / or dependence on others ».
It is difficult to establish in the different series what number of patients would fit within this definition Hondrocream. In some series, Up to 50% of patients have some degree of work disability within the first 10 years of arthritis evolution,
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